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Secondary Causes of Restless Leg Syndrome

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Updated February 24, 2014

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

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Multiple Sclerosis

There is a growing body of evidence that multiple sclerosis seems to be associated with an increased risk of RLS. Some of the studies are conflicting, however. In one of the larger studies that included 1,500 subjects, the prevalence of RLS was 19 percent in people with MS compared to only 4 percent of those people without it.

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