Beyond the conditions described above, there are many other disorders that seem to be associated with RLS symptoms. These include:
- Obesity
- Hypothyroidism
- High blood pressure
- Heart disease
- Peripheral neuropathies
- Vitamin deficiencies
- Excessive caffeine intake
- Low blood sugar
- Lumbosacral radiculopathy
- Spinal stenosis
- Use of mianserin (an antidepressant medication)
Sources:
Allen, RP et al. “MRI measurement of brain iron in patients with restless legs syndrome.” Neurology 2001; 56:263.
Connor, JR et al. “Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome.” Neurology 2003; 61:304.
Earley, CJ et al. “Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome.” Neurology 2000; 54:1698.
Kavanagh, D et al. “Restless legs syndrome in patients on dialysis.” Am J Kidney Dis 2004; 43:763.
Lee, JE et al. “Factors contributing to the development of restless legs syndrome in patients with Parkinson disease.” Mov Disord 2009; 24:579.
Manconi, M et al. “Restless legs syndrome and pregnancy.” Neurology 2004; 63:1065. American Academy of Sleep Medicine. “International classification of sleep disorders.” 2nd edition. 2005.
Manconi, M et al. “Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study.” Sleep 2008; 31:944.
Merlino, G. et al. “Association of restless legs syndrome and quality of sleep in type 2 diabetes: a case-control study.” Sleep 2007; 30:866.
Walters, A. “Restless legs syndrome and periodic limb movements of sleep.” Continuum. Neurol 2007;13(3):115-138.
