We know that light levels impact your sleepiness. How this works is only crudely understood. We know that the hormone melatonin plays a role, but current understand is pretty crude.
Researchers found that in mice, a specific type of cell (called a retinal ganglion cells), when shut off, eliminate the impact of light levels on sleep. It may be possible to trigger the sleep response through stimulating these cells (causing the body to go into it's own sleep cycle rather than overpowering it with medications and supplements) .
Of course, they haven't even been able to use this pathway to make mice sleepy yet, but it does show some interesting new directions for sleep medications.
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